Nisin is a unique short chain poly cyclic peptide containing 34 amino acids and it can boast of some special uncommon amino acids like lanthionine, methyl lanthionine, didehydro alanine and didehydro amino butyric acid. The variants of Nisin differ basically in terms of the number of amino acids contained in the polypeptide varying between 24 and 34 amino acid moieties per molecule. Their excellent solubility in water, proven safety for humans and high effectiveness at low concentrations make them ideal for preservation of many foods. More important they are digested in the GI like any other peptides and proteins leaving no traces that can cause problem. Added to this it has high resistance against acidic environment and commonly encounterd processing temperatures. It is used in a variety of foods that include milk and milk products, meat and derived products, poultry meat, fish products, canned foods, fruit juices, plant proteins, fast food preparations and health care products. Unlike conventional chemical preservatives, Nisin action is independent of pH and there for are excellently suited for extending the life of many traditional food products of India.